biogrid - data quality

Dataset statistics

Number of variables	37
Number of observations	697802
Missing cells	809
Missing cells (%)	< 0.1%
Duplicate rows	0
Duplicate rows (%)	0.0%
Total size in memory	197.0 MiB
Average record size in memory	296.0 B

Variable types

CAT	29
NUM	6
UNSUPPORTED	2

Warnings

`Tags` has constant value "697802"	Constant
`Source Database` has constant value "697802"	Constant
`Systematic Name Interactor A` has a high cardinality: 6052 distinct values	High cardinality
`Systematic Name Interactor B` has a high cardinality: 7884 distinct values	High cardinality
`Official Symbol Interactor A` has a high cardinality: 17561 distinct values	High cardinality
`Official Symbol Interactor B` has a high cardinality: 23156 distinct values	High cardinality
`Synonyms Interactor A` has a high cardinality: 15264 distinct values	High cardinality
`Synonyms Interactor B` has a high cardinality: 19520 distinct values	High cardinality
`Author` has a high cardinality: 30284 distinct values	High cardinality
`Publication Source` has a high cardinality: 32416 distinct values	High cardinality
`Qualifications` has a high cardinality: 11876 distinct values	High cardinality
`SWISS-PROT Accessions Interactor A` has a high cardinality: 17157 distinct values	High cardinality
`TREMBL Accessions Interactor A` has a high cardinality: 7118 distinct values	High cardinality
`REFSEQ Accessions Interactor A` has a high cardinality: 17535 distinct values	High cardinality
`SWISS-PROT Accessions Interactor B` has a high cardinality: 21620 distinct values	High cardinality
`TREMBL Accessions Interactor B` has a high cardinality: 8680 distinct values	High cardinality
`REFSEQ Accessions Interactor B` has a high cardinality: 22371 distinct values	High cardinality
`Ontology Term IDs` has a high cardinality: 480 distinct values	High cardinality
`Ontology Term Names` has a high cardinality: 474 distinct values	High cardinality
`Ontology Term Categories` has a high cardinality: 104 distinct values	High cardinality
`Ontology Term Qualifier IDs` has a high cardinality: 119 distinct values	High cardinality
`Ontology Term Qualifier Names` has a high cardinality: 118 distinct values	High cardinality
`Organism Name Interactor A` has a high cardinality: 55 distinct values	High cardinality
`Organism Name Interactor B` has a high cardinality: 52 distinct values	High cardinality
`Organism ID Interactor A` is highly correlated with `BioGRID ID Interactor A`	High correlation
`BioGRID ID Interactor A` is highly correlated with `Organism ID Interactor A`	High correlation
`Experimental System Type` is highly correlated with `Experimental System`	High correlation
`Experimental System` is highly correlated with `Experimental System Type`	High correlation
`BioGRID ID Interactor B` is highly skewed (γ1 = 20.03093449)	Skewed
`Organism ID Interactor B` is highly skewed (γ1 = 45.9750313)	Skewed
`#BioGRID Interaction ID` has unique values	Unique
`Entrez Gene Interactor A` is an unsupported type, check if it needs cleaning or further analysis	Unsupported
`Score` is an unsupported type, check if it needs cleaning or further analysis	Unsupported

Reproduction

Analysis started	2020-11-18 22:48:32.888194
Analysis finished	2020-11-18 22:49:44.624819
Duration	1 minute and 11.74 seconds
Software version	pandas-profiling v2.9.0
Download configuration	config.yaml

#BioGRID Interaction ID
Real number (ℝ_≥0)

UNIQUE

Distinct	697802
Distinct (%)	100.0%
Missing	0
Missing (%)	0.0%
Infinite	0
Infinite (%)	0.0%

Mean	1791418.342
Minimum	103
Maximum	2876329
Zeros	0
Zeros (%)	0.0%
Memory size	5.3 MiB

Quantile statistics

Minimum	103
5-th percentile	314839.05
Q1	923460.25
median	2226809.5
Q3	2635824.75
95-th percentile	2824468.95
Maximum	2876329
Range	2876226
Interquartile range (IQR)	1712364.5

Descriptive statistics

Standard deviation	889127.0724
Coefficient of variation (CV)	0.4963257614
Kurtosis	-1.505500948
Mean	1791418.342
Median Absolute Deviation (MAD)	620866
Skewness	-0.2900035311
Sum	1.250055302e+12
Variance	7.905469509e+11
Monotocity	Strictly increasing

Histogram with fixed size bins (bins=50)

Value	Count	Frequency (%)
1050623	1	< 0.1%
904467	1	< 0.1%
894238	1	< 0.1%
2792422	1	< 0.1%
892185	1	< 0.1%
2239327	1	< 0.1%
912663	1	< 0.1%
2226999	1	< 0.1%
2724483	1	< 0.1%
914708	1	< 0.1%
Other values (697792)	697792	> 99.9%

Minimum 5 values
Maximum 5 values

Value	Count	Frequency (%)
103	1	< 0.1%
117	1	< 0.1%
183	1	< 0.1%
278	1	< 0.1%
418	1	< 0.1%

Value	Count	Frequency (%)
2876329	1	< 0.1%
2876328	1	< 0.1%
2876327	1	< 0.1%
2876326	1	< 0.1%
2876325	1	< 0.1%

Entrez Gene Interactor A
Unsupported

REJECTED
UNSUPPORTED

Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

Entrez Gene Interactor B
Real number (ℝ_≥0)

Distinct	23834
Distinct (%)	3.4%
Missing	0
Missing (%)	0.0%
Infinite	0
Infinite (%)	0.0%

Mean	413409.8477
Minimum	1
Maximum	107983993
Zeros	0
Zeros (%)	0.0%
Memory size	5.3 MiB

Quantile statistics

Minimum	1
5-th percentile	973
Q1	5394
median	9631
Q3	55095
95-th percentile	220929
Maximum	107983993
Range	107983992
Interquartile range (IQR)	49701

Descriptive statistics

Standard deviation	6027665.675
Coefficient of variation (CV)	14.58036307
Kurtosis	271.5020809
Mean	413409.8477
Median Absolute Deviation (MAD)	7540
Skewness	16.51891519
Sum	2.884782185e+11
Variance	3.633275349e+13
Monotocity	Not monotonic

Histogram with fixed size bins (bins=50)

Value	Count	Frequency (%)
351	2098	0.3%
7157	1866	0.3%
7316	1391	0.2%
4193	982	0.1%
3065	946	0.1%
3320	885	0.1%
3312	870	0.1%
2033	756	0.1%
7415	725	0.1%
1499	717	0.1%
Other values (23824)	686566	98.4%

Minimum 5 values
Maximum 5 values

Value	Count	Frequency (%)
1	12	< 0.1%
2	63	< 0.1%
9	4	< 0.1%
10	19	< 0.1%
12	30	< 0.1%

Value	Count	Frequency (%)
107983993	3	< 0.1%
107282092	1	< 0.1%
104355295	1	< 0.1%
104355133	1	< 0.1%
104326058	1	< 0.1%

BioGRID ID Interactor A
Real number (ℝ_≥0)

HIGH CORRELATION

Distinct	17907
Distinct (%)	2.6%
Missing	0
Missing (%)	0.0%
Infinite	0
Infinite (%)	0.0%

Mean	257469.8067
Minimum	1582
Maximum	4383954
Zeros	0
Zeros (%)	0.0%
Memory size	5.3 MiB

Quantile statistics

Minimum	1582
5-th percentile	107331
Q1	110846
median	114798
Q3	120903
95-th percentile	214351
Maximum	4383954
Range	4382372
Interquartile range (IQR)	10057

Descriptive statistics

Standard deviation	740311.4648
Coefficient of variation (CV)	2.875333129
Kurtosis	26.50037553
Mean	257469.8067
Median Absolute Deviation (MAD)	4797
Skewness	5.309161984
Sum	1.79662946e+11
Variance	5.48061065e+11
Monotocity	Not monotonic

Histogram with fixed size bins (bins=50)

Value	Count	Frequency (%)
117452	3049	0.4%
121697	2971	0.4%
108403	2624	0.4%
110694	2521	0.4%
113500	2498	0.4%
108404	2329	0.3%
4383871	2223	0.3%
108276	2103	0.3%
113010	2070	0.3%
4383846	2059	0.3%
Other values (17897)	673355	96.5%

Minimum 5 values
Maximum 5 values

Value	Count	Frequency (%)
1582	1	< 0.1%
2397	1	< 0.1%
2856	1	< 0.1%
2918	1	< 0.1%
3204	1	< 0.1%

Value	Count	Frequency (%)
4383954	619	0.1%
4383953	10	< 0.1%
4383952	3	< 0.1%
4383951	9	< 0.1%
4383950	83	< 0.1%

BioGRID ID Interactor B
Real number (ℝ_≥0)

SKEWED

Distinct	23834
Distinct (%)	3.4%
Missing	0
Missing (%)	0.0%
Infinite	0
Infinite (%)	0.0%

Mean	127133.8181
Minimum	104
Maximum	4383941
Zeros	0
Zeros (%)	0.0%
Memory size	5.3 MiB

Quantile statistics

Minimum	104
5-th percentile	107343
Q1	111362
median	114954
Q3	120446
95-th percentile	129022
Maximum	4383941
Range	4383837
Interquartile range (IQR)	9084

Descriptive statistics

Standard deviation	147327.3734
Coefficient of variation (CV)	1.158837009
Kurtosis	466.2855914
Mean	127133.8181
Median Absolute Deviation (MAD)	4420
Skewness	20.03093449
Sum	8.871423251e+10
Variance	2.170535496e+10
Monotocity	Not monotonic

Histogram with fixed size bins (bins=50)

Value	Count	Frequency (%)
106848	2098	0.3%
113010	1866	0.3%
113164	1391	0.2%
110358	982	0.1%
109315	946	0.1%
109552	885	0.1%
109544	870	0.1%
108347	756	0.1%
113258	725	0.1%
107880	717	0.1%
Other values (23824)	686566	98.4%

Minimum 5 values
Maximum 5 values

Value	Count	Frequency (%)
104	1	< 0.1%
395	1	< 0.1%
1671	1	< 0.1%
1933	1	< 0.1%
2552	1	< 0.1%

Value	Count	Frequency (%)
4383941	2	< 0.1%
4383923	1	< 0.1%
4383922	1	< 0.1%
4383920	6	< 0.1%
4383919	3	< 0.1%

Systematic Name Interactor A
Categorical

HIGH CARDINALITY

Distinct	6052
Distinct (%)	0.9%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	478496
MSTP054	3049
RP1-130E4.1	2624
GU280_gp08	2223
GU280_gp05	2059
Other values (6047)	209351

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	478496	68.6%
MSTP054	3049	0.4%
RP1-130E4.1	2624	0.4%
GU280_gp08	2223	0.3%
GU280_gp05	2059	0.3%
GU280_gp01_nsp4	1841	0.3%
GU280_gp01_nsp6	1585	0.2%
P/OKcl.14	1541	0.2%
GU280_gp07	1516	0.2%
RES4-26	1412	0.2%
Other values (6042)	201456	28.9%

Frequencies of value counts

Unique

Unique	1180 ?
Unique (%)	0.2%

Histogram of lengths of the category

Length

Max length	25
Median length	1
Mean length	4.129187076
Min length	1

Systematic Name Interactor B
Categorical

HIGH CARDINALITY

Distinct	7884
Distinct (%)	1.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	493420
RP4-811H24.2	946
RP1-85F18.1	756
OK/SW-cl.35	717
RP11-174I10.1	533
Other values (7879)	201430

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	493420	70.7%
RP4-811H24.2	946	0.1%
RP1-85F18.1	756	0.1%
OK/SW-cl.35	717	0.1%
RP11-174I10.1	533	0.1%
LA16c-313D11.6	512	0.1%
CTA-216E10.7	510	0.1%
RP1-302G2.1	496	0.1%
RP11-125A15.2	495	0.1%
RP11-575L7.1	493	0.1%
Other values (7874)	198924	28.5%

Frequencies of value counts

Unique

Unique	2549 ?
Unique (%)	0.4%

Histogram of lengths of the category

Length

Max length	25
Median length	1
Mean length	3.852918163
Min length	1

Official Symbol Interactor A
Categorical

HIGH CARDINALITY

Distinct	17561
Distinct (%)	2.5%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

KIAA1429	3049
PLEKHA4	2971
ESR1	2624
MYC	2521
TRIM25	2498
Other values (17556)	684139

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
KIAA1429	3049	0.4%
PLEKHA4	2971	0.4%
ESR1	2624	0.4%
MYC	2521	0.4%
TRIM25	2498	0.4%
ORF7b	2476	0.4%
ESR2	2329	0.3%
M	2185	0.3%
EGFR	2103	0.3%
TP53	2071	0.3%
Other values (17551)	672975	96.4%

Frequencies of value counts

Unique

Unique	2527 ?
Unique (%)	0.4%

Histogram of lengths of the category

Length

Max length	15
Median length	5
Mean length	5.084108386
Min length	1

Official Symbol Interactor B
Categorical

HIGH CARDINALITY

Distinct	23156
Distinct (%)	3.3%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

APP	2098
TP53	1868
UBC	1399
MDM2	982
HDAC1	946
Other values (23151)	690509

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
APP	2098	0.3%
TP53	1868	0.3%
UBC	1399	0.2%
MDM2	982	0.1%
HDAC1	946	0.1%
HSP90AA1	888	0.1%
HSPA8	875	0.1%
EP300	756	0.1%
VCP	725	0.1%
CTNNB1	717	0.1%
Other values (23146)	686548	98.4%

Frequencies of value counts

Unique

Unique	5630 ?
Unique (%)	0.8%

Histogram of lengths of the category

Length

Max length	22
Median length	5
Mean length	5.223609276
Min length	1

Synonyms Interactor A
Categorical

HIGH CARDINALITY

Distinct	15264
Distinct (%)	2.2%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	54173
fSAP121	3049
PEPP1	2971
ER\|ESR\|ESRA\|ESTRR\|Era\|NR3A1	2624
MRTL\|MYCC\|bHLHe39\|c-Myc	2521
Other values (15259)	632464

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	54173	7.8%
fSAP121	3049	0.4%
PEPP1	2971	0.4%
ER\|ESR\|ESRA\|ESTRR\|Era\|NR3A1	2624	0.4%
MRTL\|MYCC\|bHLHe39\|c-Myc	2521	0.4%
EFP\|RNF147\|Z147\|ZNF147	2498	0.4%
ER-BETA\|ESR-BETA\|ESRB\|ESTRB\|Erb\|NR3A2	2329	0.3%
SARS-CoV2 ORF7b\|SARS-CoV-2 ORF7b\|7b\|NS7B_SARS2\|PRO_0000449799	2223	0.3%
ERBB\|ERBB1\|HER1\|NISBD2\|PIG61\|mENA	2103	0.3%
BCC7\|LFS1\|P53\|TRP53	2070	0.3%
Other values (15254)	621241	89.0%

Frequencies of value counts

Unique

Unique	2113 ?
Unique (%)	0.3%

Histogram of lengths of the category

Length

Max length	258
Median length	17
Mean length	22.17586651
Min length	1

Synonyms Interactor B
Categorical

HIGH CARDINALITY

Distinct	19520
Distinct (%)	2.8%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	61246
AAA\|ABETA\|ABPP\|AD1\|APPI\|CTFgamma\|CVAP\|PN-II\|PN2	2098
BCC7\|LFS1\|P53\|TRP53	1866
HMG20	1391
ACTFS\|HDMX\|hdm2	982
Other values (19515)	630219

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	61246	8.8%
AAA\|ABETA\|ABPP\|AD1\|APPI\|CTFgamma\|CVAP\|PN-II\|PN2	2098	0.3%
BCC7\|LFS1\|P53\|TRP53	1866	0.3%
HMG20	1391	0.2%
ACTFS\|HDMX\|hdm2	982	0.1%
GON-10\|HD1\|RPD3\|RPD3L1	946	0.1%
EL52\|HSP86\|HSP89A\|HSP90A\|HSP90N\|HSPC1\|HSPCA\|HSPCAL1\|HSPCAL4\|HSPN\|Hsp89\|Hsp90\|LAP-2\|LAP2	885	0.1%
HEL-33\|HEL-S-72p\|HSC54\|HSC70\|HSC71\|HSP71\|HSP73\|HSPA10\|LAP-1\|LAP1\|NIP71	870	0.1%
KAT3B\|RSTS2\|p300	756	0.1%
ALS14\|HEL-220\|HEL-S-70\|IBMPFD\|IBMPFD1\|TERA\|p97	725	0.1%
Other values (19510)	626037	89.7%

Frequencies of value counts

Unique

Unique	4618 ?
Unique (%)	0.7%

Histogram of lengths of the category

Length

Max length	463
Median length	16
Mean length	19.49409861
Min length	1

Experimental System
Categorical

HIGH CORRELATION

Distinct	27
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

Affinity Capture-MS	302710
Two-hybrid	112942
Affinity Capture-Western	70201
Proximity Label-MS	68665
Co-fractionation	45674
Other values (22)	97610

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
Affinity Capture-MS	302710	43.4%
Two-hybrid	112942	16.2%
Affinity Capture-Western	70201	10.1%
Proximity Label-MS	68665	9.8%
Co-fractionation	45674	6.5%
Reconstituted Complex	36936	5.3%
Affinity Capture-RNA	13271	1.9%
Biochemical Activity	12692	1.8%
Protein-RNA	7282	1.0%
Negative Genetic	4554	0.7%
Other values (17)	22875	3.3%

Frequencies of value counts

Unique

Unique	0 ?
Unique (%)	0.0%

Histogram of lengths of the category

Length

Max length	29
Median length	19
Mean length	17.68705593
Min length	3

Experimental System Type
Categorical

HIGH CORRELATION

Distinct	2
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

physical	686776
genetic	11026

Frequencies
Length

Value	Count	Frequency (%)
physical	686776	98.4%
genetic	11026	1.6%

Frequencies of value counts

Unique

Unique	0 ?
Unique (%)	0.0%

Histogram of lengths of the category

Length

Max length	8
Median length	8
Mean length	7.984198956
Min length	7

Author
Categorical

HIGH CARDINALITY

Distinct	30284
Distinct (%)	4.3%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

Huttlin EL (2017)	56473
Luck K (2020)	52414
Hein MY (2015)	29164
Huttlin EL (2015)	23712
Wan C (2015)	16795
Other values (30279)	519244

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
Huttlin EL (2017)	56473	8.1%
Luck K (2020)	52414	7.5%
Hein MY (2015)	29164	4.2%
Huttlin EL (2015)	23712	3.4%
Wan C (2015)	16795	2.4%
Antonicka H (2020)	14772	2.1%
Rolland T (2014)	13940	2.0%
Havugimana PC (2012)	13918	2.0%
Capalbo L (2019)	8989	1.3%
Samavarchi-Tehrani P (2020)	7810	1.1%
Other values (30274)	459815	65.9%

Frequencies of value counts

Unique

Unique	6944 ?
Unique (%)	1.0%

Histogram of lengths of the category

Length

Max length	37
Median length	15
Mean length	15.59832015
Min length	10

Publication Source
Categorical

HIGH CARDINALITY

Distinct	32416
Distinct (%)	4.6%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

PUBMED:28514442	56473
PUBMED:32296183	52414
PUBMED:26496610	29164
PUBMED:26186194	23712
PUBMED:26344197	16795
Other values (32411)	519244

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
PUBMED:28514442	56473	8.1%
PUBMED:32296183	52414	7.5%
PUBMED:26496610	29164	4.2%
PUBMED:26186194	23712	3.4%
PUBMED:26344197	16795	2.4%
PUBMED:32877691	14772	2.1%
PUBMED:25416956	13940	2.0%
PUBMED:22939629	13918	2.0%
PUBMED:31586073	8989	1.3%
DOI:10.1101/2020.09.03.282103	7810	1.1%
Other values (32406)	459815	65.9%

Frequencies of value counts

Unique

Unique	7616 ?
Unique (%)	1.1%

Histogram of lengths of the category

Length

Max length	31
Median length	15
Mean length	15.37272321
Min length	11

Organism ID Interactor A
Real number (ℝ_≥0)

HIGH CORRELATION

Distinct	55
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Infinite	0
Infinite (%)	0.0%

Mean	87989.69908
Minimum	3702
Maximum	2697049
Zeros	0
Zeros (%)	0.0%
Memory size	5.3 MiB

Quantile statistics

Minimum	3702
5-th percentile	9606
Q1	9606
median	9606
Q3	9606
95-th percentile	10090
Maximum	2697049
Range	2693347
Interquartile range (IQR)	0

Descriptive statistics

Standard deviation	443491.2533
Coefficient of variation (CV)	5.040263325
Kurtosis	30.23109541
Mean	87989.69908
Median Absolute Deviation (MAD)	0
Skewness	5.655180996
Sum	6.1399388e+10
Variance	1.966844918e+11
Monotocity	Not monotonic

Histogram with fixed size bins (bins=50)

Value	Count	Frequency (%)
9606	649680	93.1%
2697049	19336	2.8%
10090	18982	2.7%
559292	2378	0.3%
11676	1670	0.2%
694009	1247	0.2%
10116	876	0.1%
37296	784	0.1%
11103	517	0.1%
10376	360	0.1%
Other values (45)	1972	0.3%

Minimum 5 values
Maximum 5 values

Value	Count	Frequency (%)
3702	65	< 0.1%
3988	3	< 0.1%
4113	1	< 0.1%
6239	36	< 0.1%
7227	214	< 0.1%

Value	Count	Frequency (%)
2697049	19336	2.8%
1335626	306	< 0.1%
694009	1247	0.2%
559292	2378	0.3%
511145	2	< 0.1%

Organism ID Interactor B
Real number (ℝ_≥0)

SKEWED

Distinct	52
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Infinite	0
Infinite (%)	0.0%

Mean	11102.7769
Minimum	3702
Maximum	2697049
Zeros	0
Zeros (%)	0.0%
Memory size	5.3 MiB

Quantile statistics

Minimum	3702
5-th percentile	9606
Q1	9606
median	9606
Q3	9606
95-th percentile	9606
Maximum	2697049
Range	2693347
Interquartile range (IQR)	0

Descriptive statistics

Standard deviation	35650.867
Coefficient of variation (CV)	3.210986524
Kurtosis	3028.190117
Mean	11102.7769
Median Absolute Deviation (MAD)	0
Skewness	45.9750313
Sum	7747539926
Variance	1270984318
Monotocity	Not monotonic

Histogram with fixed size bins (bins=50)

Value	Count	Frequency (%)
9606	689010	98.7%
10090	4321	0.6%
559292	1115	0.2%
10116	991	0.1%
284812	586	0.1%
11676	363	0.1%
9913	147	< 0.1%
3702	129	< 0.1%
10298	110	< 0.1%
7227	86	< 0.1%
Other values (42)	944	0.1%

Minimum 5 values
Maximum 5 values

Value	Count	Frequency (%)
3702	129	< 0.1%
3988	2	< 0.1%
4577	1	< 0.1%
6239	17	< 0.1%
7227	86	< 0.1%

Value	Count	Frequency (%)
2697049	63	< 0.1%
1335626	7	< 0.1%
694009	49	< 0.1%
559292	1115	0.2%
511145	1	< 0.1%

Throughput
Categorical

Distinct	3
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

High Throughput	533242
Low Throughput	163319
High Throughput\|Low Throughput	1241

Frequencies
Length

Value	Count	Frequency (%)
High Throughput	533242	76.4%
Low Throughput	163319	23.4%
High Throughput\|Low Throughput	1241	0.2%

Frequencies of value counts

Unique

Unique	0 ?
Unique (%)	0.0%

Histogram of lengths of the category

Length

Max length	30
Median length	15
Mean length	14.79262885
Min length	14

Score
Unsupported

REJECTED
UNSUPPORTED

Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

Modification
Categorical

Distinct	19
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	685110
Phosphorylation	5668
Ubiquitination	3726
Deubiquitination	613
Acetylation	570
Other values (14)	2115

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	685110	98.2%
Phosphorylation	5668	0.8%
Ubiquitination	3726	0.5%
Deubiquitination	613	0.1%
Acetylation	570	0.1%
Proteolytic Processing	451	0.1%
Sumoylation	385	0.1%
Methylation	332	< 0.1%
Dephosphorylation	268	< 0.1%
No Modification	229	< 0.1%
Other values (9)	450	0.1%

Frequencies of value counts

Unique

Unique	0 ?
Unique (%)	0.0%

Histogram of lengths of the category

Length

Max length	22
Median length	1
Mean length	1.247262117
Min length	1

Qualifications
Categorical

HIGH CARDINALITY

Distinct	11876
Distinct (%)	1.7%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	326390
This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.	52414
Quantitative scores are a modified CompPASS score derived from Sowa et al., Cell, 2009 (PMID 19615732). The cut-off threshold is > 0.75.	45305
interaction detected by quantitative BAC-GFP interactomics (QUBIC)	29161
Interaction also contained in second paper after re-analysis of the data, Architecture of the human interactome defines protein communities and disease networks, PUBMED:28514442\|Quantitative scores are a modified CompPASS score derived from Sowa et al., Cell, 2009 (PMID 19615732). The cut-off threshold is > 0.75.	17440
Other values (11871)	227092

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	326390	46.8%
This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.	52414	7.5%
Quantitative scores are a modified CompPASS score derived from Sowa et al., Cell, 2009 (PMID 19615732). The cut-off threshold is > 0.75.	45305	6.5%
interaction detected by quantitative BAC-GFP interactomics (QUBIC)	29161	4.2%
Interaction also contained in second paper after re-analysis of the data, Architecture of the human interactome defines protein communities and disease networks, PUBMED:28514442\|Quantitative scores are a modified CompPASS score derived from Sowa et al., Cell, 2009 (PMID 19615732). The cut-off threshold is > 0.75.	17440	2.5%
Quantitative scores are a modified CompPASS score derived from Sowa et al., Cell, 2009 (PMID 19615732). The cut-off threshold is > 0.75.\|Re-analysis of the data from the first paper, The BioPlex Network: A Systematic Exploration of the Human Interactome, PUBMED:26186194	17440	2.5%
Fractionation was combined with mass spectrometry from five diverse animal species to predict co-complex protein interactions conserved across metazoa using an integrative computational scoring procedure along with an SVM approach. The significant data set of 16655 PPI, was derived from a set of more than 1M interactions by examining a ROC curve of predicted interactions against reference annotated complexes at a 67.5% cumulative precision.	16795	2.4%
interaction assayed using BioID\|interactions were considered high confidence if they had a Bayesian False Discovery Rate of 1% or less\|the Saint Score for the interaction (or the maximum of any bait-prey combinations that had multiple scores) is shown	14551	2.1%
Denoised score >= 0.75	13898	2.0%
BioID	8367	1.2%
Other values (11866)	156041	22.4%

Frequencies of value counts

Unique

Unique	8606 ?
Unique (%)	1.2%

Histogram of lengths of the category

Length

Max length	731
Median length	11
Mean length	99.23640374
Min length	1

Tags
Categorical

CONSTANT
REJECTED

Distinct	1
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	697802

Frequencies
Length

Value	Count	Frequency (%)
-	697802	100.0%

Frequencies of value counts

Unique

Unique	0 ?
Unique (%)	0.0%

Histogram of lengths of the category

Length

Max length	1
Median length	1
Mean length	1
Min length	1

Source Database
Categorical

CONSTANT
REJECTED

Distinct	1
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

BIOGRID	697802

Frequencies
Length

Value	Count	Frequency (%)
BIOGRID	697802	100.0%

Frequencies of value counts

Unique

Unique	0 ?
Unique (%)	0.0%

Histogram of lengths of the category

Length

Max length	7
Median length	7
Mean length	7
Min length	7

SWISS-PROT Accessions Interactor A
Categorical

HIGH CARDINALITY

Distinct	17157
Distinct (%)	2.5%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	11926
P0DTD1	6551
Q69YN4	3049
Q9H4M7	2971
P03372	2624
Other values (17152)	670681

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	11926	1.7%
P0DTD1	6551	0.9%
Q69YN4	3049	0.4%
Q9H4M7	2971	0.4%
P03372	2624	0.4%
P01106	2521	0.4%
Q14258	2498	0.4%
Q92731	2329	0.3%
P0DTD8	2223	0.3%
P00533	2103	0.3%
Other values (17147)	659007	94.4%

Frequencies of value counts

Unique

Unique	2452 ?
Unique (%)	0.4%

Histogram of lengths of the category

Length

Max length	34
Median length	6
Mean length	5.948281891
Min length	1

TREMBL Accessions Interactor A
Categorical

HIGH CARDINALITY

Distinct	7118
Distinct (%)	1.0%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	364279
Q9UBT1\|G4XH65\|A8KAF4	2624
Q0PTK2\|Q7LCB3\|F1D8N3	2329
H2EHT1\|A0A087WT22\|A0A087WXZ1\|Q53GA5\|A0A087X1Q1\|K7PPA8	2070
X5DR71	1974
Other values (7113)	324526

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	364279	52.2%
Q9UBT1\|G4XH65\|A8KAF4	2624	0.4%
Q0PTK2\|Q7LCB3\|F1D8N3	2329	0.3%
H2EHT1\|A0A087WT22\|A0A087WXZ1\|Q53GA5\|A0A087X1Q1\|K7PPA8	2070	0.3%
X5DR71	1974	0.3%
A0A024RAV5\|I1SRC5\|L7RSL8	1887	0.3%
B2R4R0	1737	0.2%
E9PFZ0\|A0A024R1V0	1719	0.2%
Q6NTA2	1541	0.2%
B7Z600\|A0A024R475	1392	0.2%
Other values (7108)	316250	45.3%

Frequencies of value counts

Unique

Unique	792 ?
Unique (%)	0.1%

Histogram of lengths of the category

Length

Max length	200
Median length	1
Mean length	6.30176755
Min length	1

REFSEQ Accessions Interactor A
Categorical

HIGH CARDINALITY

Distinct	17535
Distinct (%)	2.5%
Missing	211
Missing (%)	< 0.1%
Memory size	5.3 MiB

-	9376
NP_056311\|NP_892121	3049
NP_001154826\|NP_065955	2971
NP_001116213\|NP_000116\|NP_001278159\|NP_001278170\|NP_001116212\|NP_001116214	2624
NP_002458\|NP_001341799	2521
Other values (17530)	677050

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	9376	1.3%
NP_056311\|NP_892121	3049	0.4%
NP_001154826\|NP_065955	2971	0.4%
NP_001116213\|NP_000116\|NP_001278159\|NP_001278170\|NP_001116212\|NP_001116214	2624	0.4%
NP_002458\|NP_001341799	2521	0.4%
NP_005073	2498	0.4%
NP_001201832\|NP_001428\|NP_001201831\|NP_001278641\|NP_001035365\|NP_001278652\|NP_001258805\|NP_001258806	2329	0.3%
YP_009725318	2223	0.3%
NP_001333829\|NP_001333828\|NP_958440\|NP_005219\|NP_001333827\|NP_001333826\|NP_958441\|NP_001333870\|NP_958439	2103	0.3%
NP_001119586\|NP_001119590\|NP_001119584\|NP_000537\|NP_001263627\|NP_001263626\|NP_001263625\|NP_001119588\|NP_001263628\|NP_001119587\|NP_001263624\|NP_001119585\|NP_001263690\|NP_001119589\|NP_001263689	2070	0.3%
Other values (17525)	665827	95.4%

Frequencies of value counts

Unique

Unique	2574 ?
Unique (%)	0.4%

Histogram of lengths of the category

Length

Max length	1748
Median length	22
Mean length	36.37391409
Min length	1

SWISS-PROT Accessions Interactor B
Categorical

HIGH CARDINALITY

Distinct	21620
Distinct (%)	3.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	7364
P05067	2098
P04637	1866
P0CG48	1391
Q00987	982
Other values (21615)	684101

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	7364	1.1%
P05067	2098	0.3%
P04637	1866	0.3%
P0CG48	1391	0.2%
Q00987	982	0.1%
Q13547	946	0.1%
P07900	885	0.1%
P11142	870	0.1%
P62805	830	0.1%
Q09472	756	0.1%
Other values (21610)	679814	97.4%

Frequencies of value counts

Unique

Unique	4853 ?
Unique (%)	0.7%

Histogram of lengths of the category

Length

Max length	34
Median length	6
Mean length	6.000561764
Min length	1

TREMBL Accessions Interactor B
Categorical

HIGH CARDINALITY

Distinct	8680
Distinct (%)	1.2%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	362429
B4DGD0\|E9PG40\|B4DJT9	2098
H2EHT1\|A0A087WT22\|A0A087WXZ1\|Q53GA5\|A0A087X1Q1\|K7PPA8	1866
A7UKX8\|Q96DS0\|A7UKX9\|A7UKX7\|G3XA89	982
Q6IT96	946
Other values (8675)	329481

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	362429	51.9%
B4DGD0\|E9PG40\|B4DJT9	2098	0.3%
H2EHT1\|A0A087WT22\|A0A087WXZ1\|Q53GA5\|A0A087X1Q1\|K7PPA8	1866	0.3%
A7UKX8\|Q96DS0\|A7UKX9\|A7UKX7\|G3XA89	982	0.1%
Q6IT96	946	0.1%
Q86SX1\|K9JA46	885	0.1%
V9HW22\|Q53HF2	870	0.1%
B2R4R0	830	0.1%
Q7Z6C1	756	0.1%
Q96IF9\|V9HW80	725	0.1%
Other values (8670)	325415	46.6%

Frequencies of value counts

Unique

Unique	1599 ?
Unique (%)	0.2%

Histogram of lengths of the category

Length

Max length	200
Median length	1
Mean length	6.177970255
Min length	1

REFSEQ Accessions Interactor B
Categorical

HIGH CARDINALITY

Distinct	22371
Distinct (%)	3.2%
Missing	598
Missing (%)	0.1%
Memory size	5.3 MiB

-	4033
NP_958817\|NP_958816\|NP_001191230\|NP_001191231\|NP_001191232\|NP_000475\|NP_001372182\|NP_001129488\|NP_001129603\|NP_001129601\|NP_001129602	2098
NP_001119586\|NP_001119590\|NP_001119584\|NP_000537\|NP_001263627\|NP_001263626\|NP_001263625\|NP_001119588\|NP_001263628\|NP_001119587\|NP_001263624\|NP_001119585\|NP_001263690\|NP_001119589\|NP_001263689	1866
NP_066289	1391
NP_001354919\|NP_001265391\|NP_002383\|NP_001138811\|NP_001138812\|NP_001138809	982
Other values (22366)	686834

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	4033	0.6%
NP_958817\|NP_958816\|NP_001191230\|NP_001191231\|NP_001191232\|NP_000475\|NP_001372182\|NP_001129488\|NP_001129603\|NP_001129601\|NP_001129602	2098	0.3%
NP_001119586\|NP_001119590\|NP_001119584\|NP_000537\|NP_001263627\|NP_001263626\|NP_001263625\|NP_001119588\|NP_001263628\|NP_001119587\|NP_001263624\|NP_001119585\|NP_001263690\|NP_001119589\|NP_001263689	1866	0.3%
NP_066289	1391	0.2%
NP_001354919\|NP_001265391\|NP_002383\|NP_001138811\|NP_001138812\|NP_001138809	982	0.1%
NP_004955	946	0.1%
NP_005339\|NP_001017963	885	0.1%
NP_694881\|NP_006588	870	0.1%
NP_001349772\|NP_001420	756	0.1%
NP_009057\|NP_001341857\|NP_001341856	725	0.1%
Other values (22361)	682652	97.8%

Frequencies of value counts

Unique

Unique	5303 ?
Unique (%)	0.8%

Histogram of lengths of the category

Length

Max length	1748
Median length	22
Mean length	36.95694481
Min length	1

Ontology Term IDs
Categorical

HIGH CARDINALITY

Distinct	480
Distinct (%)	0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	656309
BTO:0000007	10580
BTO:0000567	9542
BTO:0002181	5495
HP:0001507	3306
Other values (475)	12570

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	656309	94.1%
BTO:0000007	10580	1.5%
BTO:0000567	9542	1.4%
BTO:0002181	5495	0.8%
HP:0001507	3306	0.5%
BTO:0000664	1746	0.3%
PATO:0000169\|HP:0001507	1383	0.2%
HP:0001507\|PATO:0000169	1348	0.2%
HP:0001507\|BTO:0000664	1136	0.2%
BTO:0000664\|HP:0001507	1084	0.2%
Other values (470)	5873	0.8%

Frequencies of value counts

Unique

Unique	218 ?
Unique (%)	< 0.1%

Histogram of lengths of the category

Length

Max length	66
Median length	1
Mean length	1.722308047
Min length	1

Ontology Term Names
Categorical

HIGH CARDINALITY

Distinct	474
Distinct (%)	0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	656309
HEK-293 cell	10580
HeLa cell	9542
HEK-293T cell	5495
Growth abnormality	3306
Other values (469)	12570

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	656309	94.1%
HEK-293 cell	10580	1.5%
HeLa cell	9542	1.4%
HEK-293T cell	5495	0.8%
Growth abnormality	3306	0.5%
K-562 cell	1746	0.3%
viability\|Growth abnormality	1383	0.2%
Growth abnormality\|viability	1348	0.2%
Growth abnormality\|K-562 cell	1136	0.2%
K-562 cell\|Growth abnormality	1084	0.2%
Other values (464)	5873	0.8%

Frequencies of value counts

Unique

Unique	213 ?
Unique (%)	< 0.1%

Histogram of lengths of the category

Length

Max length	132
Median length	1
Mean length	1.861092402
Min length	1

Ontology Term Categories
Categorical

HIGH CARDINALITY

Distinct	104
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	656309
cell line	28527
phenotype	4447
phenotype\|phenotype	2822
phenotype\|cell type	1427
Other values (99)	4270

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	656309	94.1%
cell line	28527	4.1%
phenotype	4447	0.6%
phenotype\|phenotype	2822	0.4%
phenotype\|cell type	1427	0.2%
cell type\|phenotype	1420	0.2%
cell type	706	0.1%
disease\|cell line	492	0.1%
cell line\|disease	484	0.1%
tissue	303	< 0.1%
Other values (94)	865	0.1%

Frequencies of value counts

Unique

Unique	48 ?
Unique (%)	< 0.1%

Histogram of lengths of the category

Length

Max length	84
Median length	1
Mean length	1.588145348
Min length	1

Ontology Term Qualifier IDs
Categorical

HIGH CARDINALITY

Distinct	119
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	674907
DOID:3702	9214
-\|-	6731
DOID:8552	1737
BTO:0000414	1588
Other values (114)	3625

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	674907	96.7%
DOID:3702	9214	1.3%
-\|-	6731	1.0%
DOID:8552	1737	0.2%
BTO:0000414	1588	0.2%
-\|-\|-	512	0.1%
CL:0000066	510	0.1%
DOID:5603	338	< 0.1%
BTO:0001109	309	< 0.1%
DOID:3717	291	< 0.1%
Other values (109)	1665	0.2%

Frequencies of value counts

Unique

Unique	38 ?
Unique (%)	< 0.1%

Histogram of lengths of the category

Length

Max length	48
Median length	1
Mean length	1.211706186
Min length	1

Ontology Term Qualifier Names
Categorical

HIGH CARDINALITY

Distinct	118
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	674907
cervical adenocarcinoma	9214
-\|-	6731
epithelial cell	2098
chronic myeloid leukemia	1737
Other values (113)	3115

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	674907	96.7%
cervical adenocarcinoma	9214	1.3%
-\|-	6731	1.0%
epithelial cell	2098	0.3%
chronic myeloid leukemia	1737	0.2%
-\|-\|-	512	0.1%
acute T cell leukemia	338	< 0.1%
HCT-116 cell	309	< 0.1%
gastric adenocarcinoma	291	< 0.1%
breast adenocarcinoma	256	< 0.1%
Other values (108)	1409	0.2%

Frequencies of value counts

Unique

Unique	38 ?
Unique (%)	< 0.1%

Histogram of lengths of the category

Length

Max length	93
Median length	1
Mean length	1.479127317
Min length	1

Ontology Term Types
Categorical

Distinct	16
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

-	690218
-\|-	6779
-\|-\|-	522
undetermined	61
wild type	53
Other values (11)	169

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
-	690218	98.9%
-\|-	6779	1.0%
-\|-\|-	522	0.1%
undetermined	61	< 0.1%
wild type	53	< 0.1%
-\|-\|-\|-	52	< 0.1%
partial rescue	45	< 0.1%
-\|-\|-\|-\|-	42	< 0.1%
wild type\|-	7	< 0.1%
-\|wild type	6	< 0.1%
Other values (6)	17	< 0.1%

Frequencies of value counts

Unique

Unique	3 ?
Unique (%)	< 0.1%

Histogram of lengths of the category

Length

Max length	44
Median length	1
Mean length	1.02652185
Min length	1

Organism Name Interactor A
Categorical

HIGH CARDINALITY

Distinct	55
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

Homo sapiens	649680
Severe acute respiratory syndrome coronavirus 2	19336
Mus musculus	18982
Saccharomyces cerevisiae (S288c)	2378
Human Immunodeficiency Virus 1	1670
Other values (50)	5756

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
Homo sapiens	649680	93.1%
Severe acute respiratory syndrome coronavirus 2	19336	2.8%
Mus musculus	18982	2.7%
Saccharomyces cerevisiae (S288c)	2378	0.3%
Human Immunodeficiency Virus 1	1670	0.2%
Severe acute respiratory syndrome-related coronavirus	1247	0.2%
Rattus norvegicus	876	0.1%
Human Herpesvirus 8	784	0.1%
Hepatitus C Virus	517	0.1%
Human Herpesvirus 4	360	0.1%
Other values (45)	1972	0.3%

Frequencies of value counts

Unique

Unique	6 ?
Unique (%)	< 0.1%

Histogram of lengths of the category

Length

Max length	53
Median length	12
Mean length	13.2172536
Min length	10

Organism Name Interactor B
Categorical

HIGH CARDINALITY

Distinct	52
Distinct (%)	< 0.1%
Missing	0
Missing (%)	0.0%
Memory size	5.3 MiB

Homo sapiens	689010
Mus musculus	4321
Saccharomyces cerevisiae (S288c)	1115
Rattus norvegicus	991
Schizosaccharomyces pombe (972h)	586
Other values (47)	1779

Frequencies
Length

Common Values
Overview

Value	Count	Frequency (%)
Homo sapiens	689010	98.7%
Mus musculus	4321	0.6%
Saccharomyces cerevisiae (S288c)	1115	0.2%
Rattus norvegicus	991	0.1%
Schizosaccharomyces pombe (972h)	586	0.1%
Human Immunodeficiency Virus 1	363	0.1%
Bos taurus	147	< 0.1%
Arabidopsis thaliana (Columbia)	129	< 0.1%
Human Herpesvirus 1	110	< 0.1%
Drosophila melanogaster	86	< 0.1%
Other values (42)	944	0.1%

Frequencies of value counts

Unique

Unique	8 ?
Unique (%)	< 0.1%

Histogram of lengths of the category

Length

Max length	53
Median length	12
Mean length	12.08652311
Min length	8

Pearson's r

The Pearson's correlation coefficient (r) is a measure of linear correlation between two variables. It's value lies between -1 and +1, -1 indicating total negative linear correlation, 0 indicating no linear correlation and 1 indicating total positive linear correlation. Furthermore, r is invariant under separate changes in location and scale of the two variables, implying that for a linear function the angle to the x-axis does not affect r.

To calculate r for two variables X and Y, one divides the covariance of X and Y by the product of their standard deviations.

Spearman's ρ

The Spearman's rank correlation coefficient (ρ) is a measure of monotonic correlation between two variables, and is therefore better in catching nonlinear monotonic correlations than Pearson's r. It's value lies between -1 and +1, -1 indicating total negative monotonic correlation, 0 indicating no monotonic correlation and 1 indicating total positive monotonic correlation.

To calculate ρ for two variables X and Y, one divides the covariance of the rank variables of X and Y by the product of their standard deviations.

Kendall's τ

Similarly to Spearman's rank correlation coefficient, the Kendall rank correlation coefficient (τ) measures ordinal association between two variables. It's value lies between -1 and +1, -1 indicating total negative correlation, 0 indicating no correlation and 1 indicating total positive correlation.

To calculate τ for two variables X and Y, one determines the number of concordant and discordant pairs of observations. τ is given by the number of concordant pairs minus the discordant pairs divided by the total number of pairs.

Phik (φk)

Phik (φk) is a new and practical correlation coefficient that works consistently between categorical, ordinal and interval variables, captures non-linear dependency and reverts to the Pearson correlation coefficient in case of a bivariate normal input distribution. There is extensive documentation available here.

Cramér's V (φc)

Cramér's V is an association measure for nominal random variables. The coefficient ranges from 0 to 1, with 0 indicating independence and 1 indicating perfect association. The empirical estimators used for Cramér's V have been proved to be biased, even for large samples. We use a bias-corrected measure that has been proposed by Bergsma in 2013 that can be found here.

First rows

	#BioGRID Interaction ID	Entrez Gene Interactor A	Entrez Gene Interactor B	BioGRID ID Interactor A	BioGRID ID Interactor B	Systematic Name Interactor A	Systematic Name Interactor B	Official Symbol Interactor A	Official Symbol Interactor B	Synonyms Interactor A	Synonyms Interactor B	Experimental System	Experimental System Type	Author	Publication Source	Organism ID Interactor A	Organism ID Interactor B	Throughput	Score	Modification	Qualifications	Tags	Source Database	SWISS-PROT Accessions Interactor A	TREMBL Accessions Interactor A	REFSEQ Accessions Interactor A	SWISS-PROT Accessions Interactor B	TREMBL Accessions Interactor B	REFSEQ Accessions Interactor B	Ontology Term IDs	Ontology Term Names	Ontology Term Categories	Ontology Term Qualifier IDs	Ontology Term Qualifier Names	Ontology Term Types	Organism Name Interactor A	Organism Name Interactor B
0	103	6416	2318	112315	108607	-	-	MAP2K4	FLNC	JNKK\|JNKK1\|MAPKK4\|MEK4\|MKK4\|PRKMK4\|SAPKK-1\|SAPKK1\|SEK1\|SERK1\|SKK1	ABP-280\|ABP280A\|ABPA\|ABPL\|FLN2\|MFM5\|MPD4	Two-hybrid	physical	Marti A (1997)	PUBMED:9006895	9606	9606	Low Throughput	-	-	-	-	BIOGRID	P45985	-	NP_003001\|NP_001268364	Q14315	Q59H94	NP_001120959\|NP_001449	-	-	-	-	-	-	Homo sapiens	Homo sapiens
1	117	84665	88	124185	106603	-	-	MYPN	ACTN2	CMD1DD\|CMH22\|MYOP\|RCM4	CMD1AA	Two-hybrid	physical	Bang ML (2001)	PUBMED:11309420	9606	9606	Low Throughput	-	-	-	-	BIOGRID	Q86TC9	A0A087WX60	NP_001243197\|NP_001243196\|NP_115967	P35609	Q59FD9\|F6THM6	NP_001094\|NP_001265272\|NP_001265273	-	-	-	-	-	-	Homo sapiens	Homo sapiens
2	183	90	2339	106605	108625	-	-	ACVR1	FNTA	ACTRI\|ACVR1A\|ACVRLK2\|ALK2\|FOP\|SKR1\|TSRI	FPTA\|PGGT1A\|PTAR2	Two-hybrid	physical	Wang T (1996)	PUBMED:8599089	9606	9606	Low Throughput	-	-	-	-	BIOGRID	Q04771	D3DPA4	NP_001104537\|NP_001096	P49354	-	NP_002018	-	-	-	-	-	-	Homo sapiens	Homo sapiens
3	278	2624	5371	108894	111384	-	-	GATA2	PML	DCML\|IMD21\|MONOMAC\|NFE1B	MYL\|PP8675\|RNF71\|TRIM19	Two-hybrid	physical	Tsuzuki S (2000)	PUBMED:10938104	9606	9606	Low Throughput	-	-	-	-	BIOGRID	P23769	-	NP_001139134\|NP_116027\|NP_001139133	P29590	-	NP_150250\|NP_150253\|NP_150252\|NP_150247\|NP_150241\|NP_150242\|NP_150243\|NP_002666\|NP_150249	-	-	-	-	-	-	Homo sapiens	Homo sapiens
4	418	6118	6774	112038	112651	RP4-547C9.3	-	RPA2	STAT3	REPA2\|RP-A p32\|RP-A p34\|RPA32	ADMIO\|APRF\|HIES	Two-hybrid	physical	Kim J (2000)	PUBMED:10875894	9606	9606	Low Throughput	-	-	-	-	BIOGRID	P15927	B4DUL2	NP_001342057\|NP_002937\|NP_001284487\|NP_001342058\|NP_001273005	P40763	-	NP_644805\|NP_003141\|NP_001356447\|NP_001356443\|NP_001371920\|NP_001371913\|NP_001371917\|NP_001356445\|NP_001356446\|NP_998827\|NP_001371915\|NP_001371914\|NP_001356442\|NP_001371918\|NP_001371919\|NP_001371921\|NP_001371922\|NP_001371916\|NP_001356448\|NP_001356449\|NP_001356441	-	-	-	-	-	-	Homo sapiens	Homo sapiens
5	586	375	23163	106870	116775	-	-	ARF1	GGA3	-	-	Two-hybrid	physical	Dell'Angelica EC (2000)	PUBMED:10747089	9606	9606	Low Throughput	-	-	-	-	BIOGRID	P84077	A0A024R3Q3	NP_001019398\|NP_001019397\|NP_001649\|NP_001019399	Q9NZ52	B7Z456\|A8K6M0	NP_619525\|NP_001278571\|NP_001278570\|NP_001166175\|NP_001166174\|NP_054720	-	-	-	-	-	-	Homo sapiens	Homo sapiens
6	612	377	23647	106872	117174	-	-	ARF3	ARFIP2	-	POR1	Two-hybrid	physical	Kanoh H (1997)	PUBMED:9038142	9606	9606	Low Throughput	-	-	-	-	BIOGRID	P61204	A0A024R0Y6	NP_001650	P53365	B4DUZ3\|B4DXH2\|A0A087X1E4	NP_036534\|NP_001229785\|NP_001229784\|NP_001229783	-	-	-	-	-	-	Homo sapiens	Homo sapiens
7	617	377	27236	106872	118084	-	-	ARF3	ARFIP1	-	HSU52521	Two-hybrid	physical	Kanoh H (1997)	PUBMED:9038142	9606	9606	Low Throughput	-	-	-	-	BIOGRID	P61204	A0A024R0Y6	NP_001650	P53367	B4E273\|B4DS69\|Q8N8M9	NP_001020764\|NP_001020766\|NP_001274362\|NP_001274360\|NP_001274361\|NP_055262	-	-	-	-	-	-	Homo sapiens	Homo sapiens
8	663	54464	226	119970	106728	-	-	XRN1	ALDOA	SEP1	ALDA\|GSD12\|HEL-S-87p	Two-hybrid	physical	Lehner B (2004)	PUBMED:15231747	9606	9606	High Throughput	-	-	-	-	BIOGRID	Q8IZH2	-	NP_001269786\|NP_061874\|NP_001269788	P04075	V9HWN7	NP_001121089\|NP_908932\|NP_908930\|NP_001230106\|NP_000025	-	-	-	-	-	-	Homo sapiens	Homo sapiens
9	866	351	10513	106848	115769	-	-	APP	APPBP2	AAA\|ABETA\|ABPP\|AD1\|APPI\|CTFgamma\|CVAP\|PN-II\|PN2	APP-BP2\|HS.84084\|PAT1	Two-hybrid	physical	Zheng P (1998)	PUBMED:9843960	9606	9606	Low Throughput	-	-	-	-	BIOGRID	P05067	B4DGD0\|E9PG40\|B4DJT9	NP_958817\|NP_958816\|NP_001191230\|NP_001191231\|NP_001191232\|NP_000475\|NP_001372182\|NP_001129488\|NP_001129603\|NP_001129601\|NP_001129602	Q92624	A0A024QZ47	NP_001269405\|NP_006371	-	-	-	-	-	-	Homo sapiens	Homo sapiens

Last rows

	#BioGRID Interaction ID	Entrez Gene Interactor A	Entrez Gene Interactor B	BioGRID ID Interactor A	BioGRID ID Interactor B	Systematic Name Interactor A	Systematic Name Interactor B	Official Symbol Interactor A	Official Symbol Interactor B	Synonyms Interactor A	Synonyms Interactor B	Experimental System	Experimental System Type	Author	Publication Source	Organism ID Interactor A	Organism ID Interactor B	Throughput	Score	Modification	Qualifications	Tags	Source Database	SWISS-PROT Accessions Interactor A	TREMBL Accessions Interactor A	REFSEQ Accessions Interactor A	SWISS-PROT Accessions Interactor B	TREMBL Accessions Interactor B	REFSEQ Accessions Interactor B	Ontology Term IDs	Ontology Term Names	Ontology Term Categories	Ontology Term Qualifier IDs	Ontology Term Qualifier Names	Ontology Term Types	Organism Name Interactor A	Organism Name Interactor B
697792	2876320	14254598	7037	4383881	112895	G128_gp06	-	ORF5	TFRC	MERS-CoV ORF5\|ORF5_CVEMC\|PRO_0000422438	CD71\|T9\|TFR\|TFR1\|TR\|TRFR\|p90	Affinity Capture-MS	physical	Gordon DE (2020)	PUBMED:33060197	1335626	9606	High Throughput	0.73055	-	High confidence interactions were identified using a two step filtering process with the final criteria including a MiST score >= 0.6, SAINTexpress BFDR =< 0.05 and average spectral counts >= 2. The MiST score is provided in the score column.	-	BIOGRID	K9N7D2	-	YP_009047208	P02786	A8K6Q8	NP_001121620\|NP_003225\|NP_001300894\|NP_001300895	-	-	-	-	-	-	Middle-East Respiratory Syndrome-related Coronavirus	Homo sapiens
697793	2876321	14254598	8266	4383881	113885	G128_gp06	XX-FW89031B12.1	ORF5	UBL4A	MERS-CoV ORF5\|ORF5_CVEMC\|PRO_0000422438	DX254E\|DXS254E\|G6PD\|GDX\|GET5\|MDY2\|TMA24\|UBL4	Affinity Capture-MS	physical	Gordon DE (2020)	PUBMED:33060197	1335626	9606	High Throughput	0.76045	-	High confidence interactions were identified using a two step filtering process with the final criteria including a MiST score >= 0.6, SAINTexpress BFDR =< 0.05 and average spectral counts >= 2. The MiST score is provided in the score column.	-	BIOGRID	K9N7D2	-	YP_009047208	P11441	-	NP_055050	-	-	-	-	-	-	Middle-East Respiratory Syndrome-related Coronavirus	Homo sapiens
697794	2876322	14254598	7917	4383881	113647	G128_gp06	DADB-70P7.10-021	ORF5	BAG6	MERS-CoV ORF5\|ORF5_CVEMC\|PRO_0000422438	BAG-6\|BAT3\|D6S52E\|G3	Affinity Capture-MS	physical	Gordon DE (2020)	PUBMED:33060197	1335626	9606	High Throughput	0.8006	-	High confidence interactions were identified using a two step filtering process with the final criteria including a MiST score >= 0.6, SAINTexpress BFDR =< 0.05 and average spectral counts >= 2. The MiST score is provided in the score column.	-	BIOGRID	K9N7D2	-	YP_009047208	P46379	-	NP_001092004\|NP_004630\|NP_542434\|NP_001186627\|NP_001186626\|NP_542433	-	-	-	-	-	-	Middle-East Respiratory Syndrome-related Coronavirus	Homo sapiens
697795	2876323	14254598	10712	4383881	115938	G128_gp06	-	ORF5	FAM189B	MERS-CoV ORF5\|ORF5_CVEMC\|PRO_0000422438	C1orf2\|COTE1	Affinity Capture-MS	physical	Gordon DE (2020)	PUBMED:33060197	1335626	9606	High Throughput	0.98371	-	High confidence interactions were identified using a two step filtering process with the final criteria including a MiST score >= 0.6, SAINTexpress BFDR =< 0.05 and average spectral counts >= 2. The MiST score is provided in the score column.	-	BIOGRID	K9N7D2	-	YP_009047208	P81408	Q9Y6J7	NP_001254537\|NP_006580\|NP_937995	-	-	-	-	-	-	Middle-East Respiratory Syndrome-related Coronavirus	Homo sapiens
697796	2876324	14254598	23155	4383881	116769	G128_gp06	RP11-475E11.6	ORF5	CLCC1	MERS-CoV ORF5\|ORF5_CVEMC\|PRO_0000422438	MCLC	Affinity Capture-MS	physical	Gordon DE (2020)	PUBMED:33060197	1335626	9606	High Throughput	0.8311	-	High confidence interactions were identified using a two step filtering process with the final criteria including a MiST score >= 0.6, SAINTexpress BFDR =< 0.05 and average spectral counts >= 2. The MiST score is provided in the score column.	-	BIOGRID	K9N7D2	-	YP_009047208	Q96S66	A0A024R0G0\|A0A024R095	NP_001364389\|NP_001364399\|NP_001364398\|NP_001364395\|NP_001364394\|NP_001364397\|NP_001364396\|NP_001364391\|NP_001364390\|NP_001364393\|NP_001364392\|NP_055942\|NP_001364387\|NP_001364388\|NP_001265132\|NP_001265131\|NP_001041675	-	-	-	-	-	-	Middle-East Respiratory Syndrome-related Coronavirus	Homo sapiens
697797	2876325	14254594	3956	4383879	110147	G128_gp02	-	S	LGALS1	spike\|MERS-CoV S\|MERS-CoV spike\|S protein\|surface\|SPIKE_CVEMC\|PRO_0000422465	GAL1\|GBP	Affinity Capture-MS	physical	Gordon DE (2020)	PUBMED:33060197	1335626	9606	High Throughput	0.81988	-	High confidence interactions were identified using a two step filtering process with the final criteria including a MiST score >= 0.6, SAINTexpress BFDR =< 0.05 and average spectral counts >= 2. The MiST score is provided in the score column.	-	BIOGRID	K9N5Q8	-	YP_009047204	P09382	-	NP_002296	-	-	-	-	-	-	Middle-East Respiratory Syndrome-related Coronavirus	Homo sapiens
697798	2876326	-	9868	4383874	115201	-	-	ORF9b	TOMM70A	SARS-CoV2 ORF9b\|SARS-CoV-2 ORF9b\|9b\|ORF9B_SARS2\|PRO_0000449657	-	Co-crystal Structure	physical	Gordon DE (2020)	PUBMED:33060197	2697049	9606	Low Throughput	-	-	Electron microscopy (EM) structure	-	BIOGRID	P0DTD2	-	-	O94826	-	NP_055635	-	-	-	-	-	-	Severe acute respiratory syndrome coronavirus 2	Homo sapiens
697799	2876327	43740577	23765	4383873	117265	GU280_gp09	-	ORF8	IL17RA	SARS-CoV2 ORF8\|SARS-CoV-2 ORF8\|8\|NS7B_SARS2\|PRO_0000449655	CANDF5\|CD217\|CDw217\|IL-17RA\|IL17R\|hIL-17R	Affinity Capture-Western	physical	Gordon DE (2020)	PUBMED:33060197	2697049	9606	Low Throughput	-	-	-	-	BIOGRID	P0DTC8	-	YP_009724396	Q96F46	-	NP_001276834\|NP_055154	-	-	-	-	-	-	Severe acute respiratory syndrome coronavirus 2	Homo sapiens
697800	2876328	-	9868	4383874	115201	-	-	ORF9b	TOMM70A	SARS-CoV2 ORF9b\|SARS-CoV-2 ORF9b\|9b\|ORF9B_SARS2\|PRO_0000449657	-	Affinity Capture-Western	physical	Gordon DE (2020)	PUBMED:33060197	2697049	9606	Low Throughput	-	-	-	-	BIOGRID	P0DTD2	-	-	O94826	-	NP_055635	-	-	-	-	-	-	Severe acute respiratory syndrome coronavirus 2	Homo sapiens
697801	2876329	-	9868	4383874	115201	-	-	ORF9b	TOMM70A	SARS-CoV2 ORF9b\|SARS-CoV-2 ORF9b\|9b\|ORF9B_SARS2\|PRO_0000449657	-	Co-purification	physical	Gordon DE (2020)	PUBMED:33060197	2697049	9606	Low Throughput	-	-	-	-	BIOGRID	P0DTD2	-	-	O94826	-	NP_055635	-	-	-	-	-	-	Severe acute respiratory syndrome coronavirus 2	Homo sapiens

Overview

Variables

Interactions

Correlations

Pearson's r

Spearman's ρ

Kendall's τ

Phik (φk)

Cramér's V (φc)

Missing values

Sample

First rows

Last rows